Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2-Reference-Cited by-同舟云学术

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Rowland Raymond¹,Brandariz-Nuñez Alberto¹^ORCID

Affiliation:

1. Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Abstract

Understanding the role of glycosylation in the virus-receptor interaction is important for developing approaches that disrupt infection. In this study, we showed that deglycosylation of both ACE2 and S had a minimal effect on the spike-ACE2 interaction.

Funder

UofI | UIUC | Center for Advanced Study, University of Illinois at Urbana-Champaign

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01199-21

Reference104 articles.

1. World Health Organization. 2020. World Health Organization coronavirus disease 2019 (COVID-19) situation report. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. A new coronavirus associated with human respiratory disease in China

4. A pneumonia outbreak associated with a new coronavirus of probable bat origin

5. Clinical and immunological features of severe and moderate coronavirus disease 2019

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