Drug-Resistant Tuberculosis on the Balkan Peninsula: Determination of Drug Resistance Mechanisms with Xpert MTB/XDR and Whole-Genome Sequencing Analysis

Author:

Truden Sara1ORCID,Sodja Eva1,Žolnir-Dovč Manca1

Affiliation:

1. University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia

Abstract

The Xpert MTB/XDR was tested on drug-resistant Mycobacterium tuberculosis complex isolates from the Balkan Peninsula. Positive Bactec MGIT 960 cultures or DNA isolates were tested as starting material.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference33 articles.

1. WHO. 2021. Global tuberculosis report 2021. Available from https://www.who.int/publications/i/item/9789240037021. WHO Geneva Switzerland.

2. What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis

3. WHO. 2021. WHO operational handbook on tuberculosis. Module 3: diagnosis: rapid diagnostics for tuberculosis detention 2021 update. Available from https://www.who.int/publications/i/item/9789240030589. WHO Geneva Switzerland.

4. WHO. 2019. WHO consolidated guidelines on drug-resistant tuberculosis treatment. WHO, Geneva, Switzerland.

5. Cepheid. 2021. Xpert MTB/XDR English package insert. Available from https://www.cepheid.com/Package%20Insert%20Files/Xpert%20MTB-XDR%20ENGLISH%20Package%20Insert%20302-3514%20Rev%20C.pdf. Accessed 11 February 2022. Cepheid AB Solna Sweden.

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