The Bladder Microbiome, Metabolome, Cytokines, and Phenotypes in Patients with Systemic Lupus Erythematosus

Author:

Liu Fengping1,Du Jingjie2,Zhai Qixiao3,Hu Jialin4,Miller Aaron W.5,Ren Tianli6,Feng Yangkun7,Jiang Peng4,Hu Lei4,Sheng Jiayi4,Gu Chaoqun4,Yan Ren8,Lv Longxian7ORCID,Wolfe Alan J.2ORCID,Feng Ninghan4

Affiliation:

1. Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China

2. Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA

3. State Key Laboratory of Food Science and Technology and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China

4. Department of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, Jiangsu, China

5. Glickman Urological and Kidney Institute, Cleveland, Ohio, USA

6. Department of Rheumatology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China

7. School of Medicine, Nantong University, Nantong, Jiangsu, China

8. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Abstract

Contrary to dogma, the human urinary bladder possesses its own unique bacterial community with alteration of composition associated with disease states. Systemic lupus erythematosus (SLE) is a complex autoimmune disease often characterized by kidney impairment.

Funder

Wuxi “Taihu Talent Plan Project” Medical and Health High-level Talents

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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