New Molecular Mechanism of Superbiofilm Elaboration in a Staphylococcus aureus Clinical Strain-Reference-Cited by-同舟云学术

New Molecular Mechanism of Superbiofilm Elaboration in a Staphylococcus aureus Clinical Strain

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yu Liansheng¹²³,Hisatsune Junzo¹²³^ORCID,Kutsuno Shoko¹²³,Sugai Motoyuki¹²³^ORCID

Affiliation:

1. Antimicrobial Resistance Research Centre, National Institute of Infectious Diseases, Tokyo, Japan

2. Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan

3. Department of Antimicrobial Resistance, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

Abstract

Poly- N -acetylglucosamine (PNAG) is a major component of S. aureus biofilm. PNAG production is mediated by the products of four genes, icaADBC encoded in the ica operon, and the major negative regulator of this operon is IcaR encoded just upstream of icaADBC .

Funder

Japan Agency for Medical Research and Development

Health and Labor Sciences Research Grant

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04425-22

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