Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds-Reference-Cited by-同舟云学术

Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Dye Keane J.¹,Vogelaar Nancy J.²³,O’Hara Megan¹,Sobrado Pablo²³⁴,Santos Webster²⁴⁵,Carlier Paul R.²⁵,Yang Zhaomin¹²⁴^ORCID

Affiliation:

1. Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA

2. Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, USA

3. Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA

4. Virginia Tech Center for Emerging, Zoonotic and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, Virginia, USA

5. Department of Chemistry, Virginia Tech, Blacksburg, Virginia, USA

Abstract

Many bacterial pathogens use their type IV pilus (T4P) to facilitate and maintain an infection in a human host. Small-molecule inhibitors of the production or assembly of the T4P are promising for the treatment and prevention of infections by these bacteria, especially in our fight against antibiotic-resistant pathogens.

Funder

National Science Foundation

Virginia Tech, College of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03877-22

Reference54 articles.

1. Type IV pili: dynamics, biophysics and functional consequences

2. Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa