Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli-Reference-Cited by-同舟云学术

Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hirakawa Hidetada¹^ORCID,Takita Ayako¹,Sato Yumika¹,Hiramoto Suguru²,Hashimoto Yusuke¹,Ohshima Noriyasu³,Minamishima Yoji A.³^ORCID,Murakami Masami²,Tomita Haruyoshi¹⁴^ORCID

Affiliation:

1. Department of Bacteriology, Gunma University Graduate School of Medicine, Gunma, Japan

2. Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan

3. Department of Biochemistry, Gunma University Graduate School of Medicine, Gunma, Japan

4. Laboratory of Bacterial Drug Resistance, Gunma University Graduate School of Medicine, Gunma, Japan

Abstract

The spread of drug-resistant bacteria is a major threat in the field of medicine. Although fosfomycin is an old type of antimicrobial agent, it has recently come back into the limelight because of its effectiveness against many drug-resistant bacteria, including quinolone-resistant and ESBL-producing bacteria.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Ministry of Health, Labour and Welfare

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05069-22

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1. Urinary Tract Infection