Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes-Reference-Cited by-同舟云学术

Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Brito Barbara P.¹^ORCID,Koong Jonathan¹,Wozniak Aniela²³⁴,Opazo-Capurro Andres³⁵^ORCID,To Joyce¹,Garcia Patricia²³⁴,Hamidian Mehrad¹^ORCID

Affiliation:

1. Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, New South Wales, Australia

2. Laboratory of Microbiology, Department of Clinical Laboratories, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

3. Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile

4. Clinical Laboratories Network, Red de Salud UC-CHRISTUS, Santiago, Chile

5. Laboratorio de Investigación en Agentes Antibacterianos, Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

Abstract

Treating infections caused by carbapenem-resistant A. baumannii (CR Ab ) has become a global challenge given that CR Ab strains are also often resistant to a wide range of antibiotics. Analysis of whole-genome sequence data is now a standard approach for studying the genomic context of antibiotic resistance genes; however, genome sequence data from South American countries are scarce.

Funder

University of Technology Sydney

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02463-22

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2. Carbapenem resistance inAcinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies