Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle-Reference-Cited by-同舟云学术

Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Huynh Trang T. X.¹,Pham Thuy X.¹,Lee Gun-Hee²,Lee Jae-Bong³,Lee Sung-Geun³,Tark Dongseob²^ORCID,Lim Yun-Sook¹,Hwang Soon B.¹⁴^ORCID

Affiliation:

1. Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, South Korea

2. Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, South Korea

3. Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, South Korea

4. Ilsong Institute of Life Science, Hallym University, Seoul, South Korea

Abstract

Tyrosine kinase has been implicated in viral replication and has become an antiviral drug target. Here, we chose two well-known receptor tyrosine kinase inhibitors, amuvatinib and imatinib, and evaluated their drug potencies against SARS-CoV-2.

Funder

Ministry of Science and ICT, South Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05105-22

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