Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage-Reference-Cited by-同舟云学术

Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Faral-Tello Paula¹^ORCID,Greif Gonzalo¹^ORCID,Romero Selva²,Cabrera Andrés¹²³,Oviedo Cristina²,González Telma²,Libisch Gabriela¹,Arévalo Ana Paula⁴,Varela Belén⁵,Verdes José Manuel⁵^ORCID,Crispo Martina⁴^ORCID,Basmadjián Yester²,Robello Carlos¹⁶^ORCID

Affiliation:

1. Laboratorio de Interacciones Hospedero Patógeno/UBM, Institut Pasteur de Montevideo, Montevideo, Uruguay

2. Departamento de Parasitología y Micología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

3. Unidad de Microbiología, Instituto de Patobiología, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay

4. Laboratory Animal Biotechnology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay

5. Unidad de Patología, Departamento de Patobiología, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay

6. Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

Abstract

The main findings of this study are that we determined that there are Trypanosoma cruzi strains adapted to transplacental transmission and completely different from the commonly used laboratory reference strains. This implies a specific strategy for the vertical transmission of Chagas disease.

Funder

ERANET-Lac

PEDECIBA-Uruguay

Agencia Nacional de Investigación e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02504-22

Reference62 articles.

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3. WHO. 2015. Chagas disease in Latin America: an epidemiological update based on 2010 estimates = Maladie de Chagas en Amérique latine: le point épidémiologique basé sur les estimations de 2010. WHO. https://apps.who.int/iris/handle/10665/242316. Retrieved 3 April 2022.

4. Congenital transmission of Chagas disease: a clinical approach

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