Three-Stage Pooled Plasma Hepatitis C Virus RNA Testing for the Identification of Acute HCV Infections in At-Risk Populations-Reference-Cited by-同舟云学术

Three-Stage Pooled Plasma Hepatitis C Virus RNA Testing for the Identification of Acute HCV Infections in At-Risk Populations

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Hsin-Yun¹²,Chiang Chieh³,Huang Sung-Hsi⁴⁵,Guo Wen-Jin⁶,Chuang Yu-Chung¹²,Huang Yi-Chia⁷,Yang Chia-Jui⁸⁹,Su Li-Hsin¹²,Chen Yi-Ting¹²,Chen Yea-Wen¹²,Hsu Fu-Chiang¹⁰¹¹,Ho Shu-Yuan¹⁰¹¹,Liu Wen-Chun¹²,Su Yi-Ching¹²,Chang Sui-Yuan¹⁰¹¹¹²,Hsiao Chin-Fu⁶,Hung Chien-Ching¹²⁵¹³¹⁴,Yu Ming-Lung¹⁵¹⁶^ORCID

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

2. Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

3. Department of Mathematics, Tamkang University, New Taipei City, Taiwan

4. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan

5. Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan

6. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

7. Department of Internal Medicine, National Taiwan University Hospital Biomedical Park Branch, Hsin-Chu, Taiwan

8. Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan

9. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

10. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

11. Department of Laboratory Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

12. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan

13. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

14. China Medical University, Taichung, Taiwan

15. Hepatobiliary Section, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

16. Hepatitis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Our three-stage pooled plasma HCV RNA testing successfully identified HCV viremia in high-risk PLWH with a testing cost reduction of 84.5%. Simulation analysis offered detailed information regarding the selection of pool and mini-pool sizes in settings of different HCV epidemiology and the performance of HCV RNA testing to optimize the cost reduction.

Funder

National Taiwan University Hospital, Taipei, Taiwan

Gilead Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02437-21

Reference26 articles.

1. Sexually acquired hepatitis C virus infection: a review

2. Sexually transmitted hepatitis C infection