Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies <i>equisimilis</i>-Reference-Cited by-同舟云学术

Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies equisimilis

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Beres Stephen B.¹^ORCID,Olsen Randall J.¹²³,Long S. Wesley¹²³^ORCID,Eraso Jesus M.¹²,Boukthir Sarrah⁴⁵⁶,Faili Ahmad⁵⁷⁸,Kayal Samer⁴⁵⁶⁸^ORCID,Musser James M.¹²³

Affiliation:

1. Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA

2. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA

3. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

4. CHU de Rennes, Service de Bacteriologie-Hygiène Hospitalière, Rennes, France

5. INSERM, CIC 1414, Rennes, France

6. Université Rennes 1, Faculté de Médecine, Rennes, France

7. Université Rennes 1, Faculté de Pharmacie, Rennes, France

8. Chemistry, Oncogenesis, Stress, and Signaling, INSERM 1242, Rennes, France

Abstract

Our studies addressed a critical knowledge gap in understanding the genomics and virulence of the bacterial pathogen Streptococcus dysgalactiae subsp. equisimilis . S. dysgalactiae subsp. equisimilis strains are responsible for a recent increase in severe human infections in some countries. We determined that certain S. dysgalactiae subsp. equisimilis strains are genetically descended from a common ancestor and that these strains can cause severe infections in a mouse model of necrotizing myositis.

Funder

Fondren Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04550-22

Reference77 articles.

1. Genetic Relationships Deduced from emm and Multilocus Sequence Typing of Invasive Streptococcus dysgalactiae subsp. equisimilis and S. canis Recovered from Isolates Collected in the United States

2. Human Infections Due toStreptococcus dysgalactiaeSubspeciesequisimilis

3. Emergent Invasive Group AStreptococcus dysgalactiaesubsp.equisimilis, United States, 2015–2018