Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine-Reference-Cited by-同舟云学术

Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nogales Aitor¹²^ORCID,Steel John³,Liu Wen-Chun⁴⁵⁶,Lowen Anice C.³^ORCID,Rodriguez Laura¹⁷,Chiem Kevin¹⁸,Cox Andrew¹,García-Sastre Adolfo⁴⁵⁹¹⁰¹¹^ORCID,Albrecht Randy A.⁴⁵^ORCID,Dewhurst Stephen¹,Martínez-Sobrido Luis¹⁸^ORCID

Affiliation:

1. Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA

2. Animal Health Research Centre (CISA), Centro Nacional Instituto de Investigación y Tecnología Agraria y Alimentaria (INIA, CSIC), Madrid, Spain

3. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan

7. Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain

8. Texas Biomedical Research Institute, San Antonio, Texas, USA

9. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

10. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

11. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Vaccination represents the most effective strategy to reduce the impact of seasonal IAV infections. Although LAIV are superior in inducing protection and sterilizing immunity, they are not recommended for many individuals who are at high risk for severe disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00078-22

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