Comparison of Nasopharyngeal and Saliva Swab Nucleic Acid Amplification and Rapid Antigen Testing To Detect Omicron SARS-CoV-2 Variant of Concern: a Prospective Clinical Trial (OMICRON)

Author:

Kritikos Antonios1,Caruana Giorgia1,Lazor-Blanchet Catherine2,Currat Michael2,Chiche Jean-Daniel3,Vollenweider Peter4,Bart Pierre-Alexandre4,Opota Onya1,Greub Gilbert1

Affiliation:

1. Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

2. Occupational Health Service, Lausanne University Hospital, Lausanne, Switzerland

3. Intensive Care Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

4. Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

The Omicron variant of concern spread rapidly since it was first reported in November 2021 and currently accounts for the vast majority of new infections worldwide. Recent reports suggest that saliva sampling might outweigh nasopharyngeal sampling for the diagnosis of the Omicron variant.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference28 articles.

1. Centers for Disease Control and Prevention. 2021. New SARS-CoV-2 variant of concern identified: Omicron (B.1.1.529) variant 2021. https://emergency.cdc.gov/han/2021/han00459.asp.

2. Centers for Disease Control and Prevention. 2021. Variant proportions. https://covid.cdc.gov/covid-data-tracker/#variant-proportions.

3. Analysis of online search trends suggests that SARS-CoV-2 Omicron (B.1.1.529) variant causes different symptoms

4. First cases of Omicron in France are exhibiting mild symptoms, November 2021–January 2022

5. Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves

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