Gut Microbiota Mediates the Therapeutic Effect of Monoclonal Anti-TLR4 Antibody on Acetaminophen-Induced Acute Liver Injury in Mice-Reference-Cited by-同舟云学术

Gut Microbiota Mediates the Therapeutic Effect of Monoclonal Anti-TLR4 Antibody on Acetaminophen-Induced Acute Liver Injury in Mice

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Xuewei¹²,Cui Qian³,Ni Juan⁴,Liu Xiaoguang⁵,Zhu Jin¹,Zhou Tingting¹,Huang HuaYing⁴,OuYang Ke⁴,Wu Yulong²,Yang Zhan¹^ORCID

Affiliation:

1. Centre for Diseases Prevention and Control of Eastern Theater, Nanjing, China

2. Binzhou Medical University, Yantai, China

3. Air Force Hospital of Eastern Theater, Nanjing, China

4. The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China

5. Department of Respiratory and Critical Care Medicine, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China

Abstract

In this study, we found the monoclonal anti-Toll-like receptor 4 antibody can alleviate APAP-induced acute liver injury through the change of the gut microbiota, metabolic pathways, and gut barrier function. This work suggested the gut microbiota can be the therapeutic target of the APAP-induced acute liver injury, and we performed the fundamental research for further research.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00647-22

Reference44 articles.

1. The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

2. Drug‐Induced Liver Injury in GI Practice