Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis-Reference-Cited by-同舟云学术

Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Di Bonaventura Giovanni¹²^ORCID,Lupetti Veronica¹²,Di Giulio Andrea³,Muzzi Maurizio³,Piccirilli Alessandra⁴^ORCID,Cariani Lisa⁵,Pompilio Arianna¹²^ORCID

Affiliation:

1. Department of Medical, Oral, and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy

2. Center for Advanced Studies and Technology, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy

3. Department of Science, University Roma Tre, Rome, Italy

4. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L’Aquila, Italy

5. Microbiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Abstract

Antibiotic resistance makes it urgent to design new strategies for treating pulmonary infections in CF patients. The repurposing approach accelerates drug discovery and development, as the drugs’ general pharmacological, pharmacokinetic, and toxicological properties are already well known.

Funder

G d'Annunzio University of Chieti-Pescara

G d'Annunzio University of Cheti-Pescara

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00352-23

Reference79 articles.

1. Opportunistic Pathogens in Cystic Fibrosis: Epidemiology and Pathogenesis of Lung Infection

2. Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients