Wnt-Independent SARS-CoV-2 Infection in Pulmonary Epithelial Cells-Reference-Cited by-同舟云学术

Wnt-Independent SARS-CoV-2 Infection in Pulmonary Epithelial Cells

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Koval Alexey¹,Xu Jiabin¹,Williams Nathalia²,Schmolke Mirco²,Krause Karl-Heinz³,Katanaev Vladimir L.¹⁴^ORCID

Affiliation:

1. Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland

2. Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

3. Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland

4. Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia

Abstract

The development of inhibitors of the SARS-CoV-2 infection remains a need of utmost importance. The Wnt signaling pathway in host cells is often implicated in infections by bacteria and viruses. In this work, we show that, despite previous indications, pharmacological modulation of the Wnt pathway does not represent a promising strategy to control SARS-CoV-2 infection in lung epithelia.

Funder

League Pulmonaire Genevoise

Swiss National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04827-22

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