Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome-Reference-Cited by-同舟云学术

Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hao Yanan¹²,Feng Yanni³,Yan Xiaowei¹,Chen Liang¹,Ma Xiangping¹,Tang Xiangfang¹,Zhong Ruqing¹,Sun Zhongyi⁴,Agarwal Manjree²,Zhang Hongfu¹²,Zhao Yong¹²^ORCID

Affiliation:

1. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of China

2. College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia

3. College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, People’s Republic of China

4. Urology Department, Shenzhen university general hospital, Shenzhen, People’s Republic of China

Abstract

HFD decreases male fertility via upsetting gut microbiota and transplantation of AOS-benefited gut microbiota (A10-FMT) improves gut microbiota to ameliorate HFD-reduced male fertility. Moreover, A10-FMT improved liver function to benefit the blood metabolome and simultaneously ameliorated the testicular microenvironment to turn the spermatogenesis process on.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00028-22

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