Effective Colonization by Nontoxigenic Clostridioides difficile REA Strain M3 (NTCD-M3) Spores following Treatment with Either Fidaxomicin or Vancomycin-Reference-Cited by-同舟云学术

Effective Colonization by Nontoxigenic Clostridioides difficile REA Strain M3 (NTCD-M3) Spores following Treatment with Either Fidaxomicin or Vancomycin

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sambol Susan P.¹,Skinner Andrew M.¹²^ORCID,Serna-Perez Fidel²,Owen Benjamin³,Gerding Dale N.²,Johnson Stuart¹²^ORCID

Affiliation:

1. Loyola University Medical Center, Department of Medicine, Maywood, Illinois, USA

2. Edward Hines Jr., VA Hospital, Research Section, Infection Diseases Section, Hines, Illinois, USA

3. Department of Chemistry, Northwestern University, Evanston, Illinois, USA

Abstract

NTCD-M3 is a novel live biotherapeutic, that has been shown in a Phase 2 clinical trial to prevent recurrence of C. difficile infection (CDI) when administered shortly after antibiotic treatment of the initial CDI episode. Fidaxomicin was not, however, in widespread use at the time this study was conducted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00517-23

Reference19 articles.

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4. Colonization for the Prevention ofClostridium difficileDisease in Hamsters

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