Network Analysis Reveals the Molecular Bases of Statin Pleiotropy That Vary with Genetic Background-Reference-Cited by-同舟云学术

Network Analysis Reveals the Molecular Bases of Statin Pleiotropy That Vary with Genetic Background

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

del Rio Hernandez Cintya E.¹²,Campbell Lani J.¹²,Atkinson Paul H.¹²,Munkacsi Andrew B.¹²^ORCID

Affiliation:

1. School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand

2. Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Wellington, New Zealand

Abstract

Atorvastatin is a highly successful drug prescribed to lower cholesterol and prevent cardiovascular disease in millions of people. Though much of its effect comes from inhibiting a key enzyme in the cholesterol biosynthetic pathway, genes in this pathway interact with genes in other pathways, resulting in 15% of patients suffering painful muscular side effects and 50% having inadequate responses.

Funder

Cancer Society of New Zealand

Maurice Wilkins Centre for Molecular Biodiscovery

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04148-22

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