Broadly Effective ACE2 Decoy Proteins Protect Mice from Lethal SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Broadly Effective ACE2 Decoy Proteins Protect Mice from Lethal SARS-CoV-2 Infection

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Lu Mengjia¹²,Yao Weitong³^ORCID,Li Yujun⁴,Ma Danting⁵,Zhang Zhaoyong⁶,Wang Haimin²,Tang Xiaojuan¹²,Wang Yanqun⁶,Li Chao²,Cheng Dechun²,Lin Hua⁷,Yin Yandong¹²,Zhao Jincun⁶^ORCID,Zhong Guocai¹²^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China

2. Shenzhen Bay Laboratory, Shenzhen, Guangdong, China

3. Hubei JiangXia Laboratory, Wuhan, Hubei, China

4. Shenzhen University School of Medicine, Shenzhen, Guangdong, China

5. Tianjin Medical University Chu Hsien-I Memorial Hospital, Tianjin, China

6. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

7. Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian, China

Abstract

Engineering soluble ACE2 proteins that function as a receptor decoy to block SARS-CoV-2 infection is a very attractive approach to creating broadly effective and hard-to-escape anti-SARS-CoV-2 agents. This article describes development of two antibody-like soluble ACE2 proteins that broadly block diverse SARS-CoV-2 variants, including Omicron.

Funder

Shenzhen Bay Laboratory

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01100-23

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