Implication of the IL-10-Expression Signature in the Pathogenicity of <i>Leptospira</i> -Infected Macrophages-Reference-Cited by-同舟云学术

Implication of the IL-10-Expression Signature in the Pathogenicity of Leptospira -Infected Macrophages

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chou Li-Fang¹^ORCID,Chen Ting-Wen²³⁴^ORCID,Yang Huang-Yu¹⁵⁶,Tian Ya-Chung¹⁵⁶,Chang Ming-Yang¹⁵⁶,Hung Cheng-Chieh¹⁵⁶,Lai Chih-Ho⁷⁸,Hsu Shen-Hsing¹,Tsai Chung-Ying¹,Ko Yi-Ching¹,Lian Jang-Hau⁹,Yang Chih-Wei¹⁵⁶^ORCID

Affiliation:

1. Kidney Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan

2. Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

3. Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

4. Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan

5. Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taiwan

6. College of Medicine, Chang Gung University, Taoyuan, Taiwan

7. Department of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan

8. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

9. Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan

Abstract

Activation of macrophages by Leptospira spp. infection is thought to be involved in the pathogenesis of leptospirosis. To evaluate the innate macrophage responses to Leptospira spp., specifically pathogenic versus nonpathogenic Leptospira spp., we characterized the entire transcriptome-wide alterations in infected macrophages.

Funder

Chang Gung Memorial Hospital, Linkou

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02595-21

Reference51 articles.

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