Metagenomic Approaches Reveal Strain Profiling and Genotyping of Klebsiella pneumoniae from Hospitalized Patients in China-Reference-Cited by-同舟云学术

Metagenomic Approaches Reveal Strain Profiling and Genotyping of Klebsiella pneumoniae from Hospitalized Patients in China

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Jiao¹,Xu Zhuofei²,Li Haibo³,Chen Fuhui⁴,Han Kaiyu⁴,Hu Xiaoman⁴,Fang Yuan²^ORCID,Chen Dechang¹

Affiliation:

1. Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Genoxor Medical Science and Technology Inc., Zhejiang, China

3. The Central Laboratory of Birth Defects Prevention and Control, Ningbo Women and Children’s Hospital, Ningbo, China

4. Department of Respiration, the Second Affiliated Hospital of Harbin Medical University, Harbin, China

Abstract

Routine culture and PCR-based molecular testing in the clinical microbiology laboratory are unable to recognize pathogens at the strain level and to detect strain-specific genetic determinants involved in virulence and resistance. To address this issue, we explored the strain-level profiling of K. pneumoniae prevalent in China based on metagenome-sequenced patient materials.

Funder

National Natural Science Foundation of China

STCSM | Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02190-21

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