Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus-Reference-Cited by-同舟云学术

Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Brignoli Tarcisio¹^ORCID,Douglas Edward¹²,Duggan Seána¹³^ORCID,Fagunloye Olayemi Grace⁴,Adhikari Rajan⁵,Aman M. Javad⁵,Massey Ruth C.¹⁶⁷⁸^ORCID

Affiliation:

1. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

2. Biology and Biochemistry Department, University of Bath, Bath, United Kingdom

3. MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom

4. School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Integrated Biotherapeutics, Inc. (IBT), Rockville, Maryland, USA

6. School of Microbiology, University College Cork, Cork, Ireland

7. School of Medicine, University College Cork, Cork, Ireland

8. APC Microbiome Ireland, University College Cork, Cork, Ireland

Abstract

The production and release of cytolytic toxins is a critical aspect for the pathogenicity of many bacterial pathogens. In this study, we demonstrate a role for wall teichoic acids, molecules that are anchored to the peptidoglycan of the bacterial cell wall, in the release of toxins from S. aureus cells into the extracellular environment.

Funder

Wellcome Trust

UKRI | Biotechnology and Biological Sciences Research Council

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01011-22

Reference53 articles.

1. Staphylococcus aureusInfections