In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
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Published:2023-02-14
Issue:1
Volume:11
Page:
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ISSN:2165-0497
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Container-title:Microbiology Spectrum
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language:en
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Short-container-title:Microbiol Spectr
Author:
Trémeaux Pauline123ORCID, Lemoine Frédéric45, Mélard Adeline12, Gousset Marine12, Boufassa Faroudy6, Orr Sylvie6, Monceaux Valérie7, Gascuel Olivier48, Lambotte Olivier9, Hocqueloux Laurent10, Saez-Cirion Asier7ORCID, Rouzioux Christine1, Avettand-Fenoel Véronique1211ORCID, Boufassa Faroudy, Orr Sylvie, Bani-Sadr Firouzé, Hentzien Maxime, Berger Jean-Luc, Kmiec Isabelle, Pichancourt Gilles, Nasri Safa, Hittinger Gilles, Lambry Véronique, Beaudrey Anne-Cécile, Pialoux Gilles, Chas Julie, Palacios Christia, Adda Anne, Viard Jean Paul, Dulucq Marie-Josée, Weiss Laurence, Karmochkine Marina, Meghadecha Mohamed, Salmon-Ceron Dominique, Piétri Marie-Pierre, Blanche Philippe, Molina Jean-Michel, Taulera Olivier, Ponscarme Diane, Delgado Bertaut Jeannine, Makhloufi Djamila, Godinot Matthieu, Artizzu Valérie, Miailhes Patrick, Cotte Laurent, Pailhes Sophie, Conrad Anne, Karkowski Ludovic, Ogoudjobi Stanislas, Yazdanpanah Yazdan, Matheron Sophie, Godard Cindy, Bernard Louis, Bastides Frédéric, Bourgault Olivier, Jacomet Christine, Goncalves Emilie, Chavanet Pascal, Piroth Lionel, Gohier Sandrine, Meybeck Agnès, Huleux Thomas, Cornavin Pauline, Debab Yasmine, Théron David, Prazuck Thierry, Hocqueloux Laurent, De Dieuleveult Barbara, Faller Jean-Pierre, Eglinger Patricia, Roblot Pascal, Plainchamp David, Aumaître Hugues, Malet Martine, Rouger Christine, Rémy Gérard, Isabelle Melle Kmiec, Delassus Jean-Luc, Devidas Alain, Froguel Eric, Tassi Sylvie, Genet Philippe, Gerbe Juliette, Patey Olivier, Laurent Richier, Drobacheff Marie-Christine, Proust Aurélie, Gil Helder, Gérard Laurence, Oksenhendler Eric, Molina Jean-Michel, Lascoux Caroline, Parlier Sylvie, Lucht Frédéric, Ronat Véronique, Dupon Michel, Dutronc Hervé, Le Puil Séverine, Neau Didier, Mercié Patrick, Morlat Philippe, Caldato Sabrina, Schmit Jean-Luc, Decaux Nathalie, Bru Jean-Pierre, Clavere Gaëlle, Lambotte Olivier, Delfraissy Jean-François, Goujard Cécile, Bourdic Katia, Vittecoq Daniel, Bolliot Claudine, Lambert Thierry, Bergmann Jean-François, Parrinello Maguy, Pichancourt Gilles, Welker Yves, Lafeuillade Alain, Philip Gisèle, Rapp Christophe, Lerondel Melle, de Truchis Pierre, Huguette Berthe, Jeantils Vincent, Mchangama Fatouma, Consigny Paul Henri, Touam Fatima, Pialoux Gilles, le Nagat Sophie, Bouchaud Olivier, Honoré Patricia, Boué François, Raho-Moussa Mariem, Viard Jean-Paul, Cros Agnès, Salmon-Céron Dominique, Pietri Marie-Pierre, Weiss Laurence, Collias Lio, Zucman David, Blétry Olivier, Bornarel Dominique, Mortier Emmanuel, Feng Zeng, Lelièvre Jean-Daniel, Katlama Christine, Dudoit Yasmine, Simon Anne, Lupin Catherine, Girard Pierre-Marie, Pauchard Michèle, Abel Sylvie, Cabié André, Fialaire Pascale, Chennebault Jean-Marie, Rehaiem Sami, de Saint Martin Luc, Perfezou ••••, Duthe Jean-Charles, Weinbreck Pierre, Genet Claire, Makhloufi Djamila, Garnier Florence, Miailhes Patrick, Ogoudjobi Stanislas, Poizot-Martin Isabelle, Fauche Olivia, Ivanova Alena, Philibert Patrick, Penda Sow Mame, Yeni Patrick, Matheron Sophie, Godard Cyndi, Raffi François, Hüe Hervé, Perré Philippe, Roger Pierre Marie, Joulie Aline, Rosenthal Éric, Michelet Christian, Souala Faouzi, Ratajczak Maja, Partisani Marialuisa, Fischer Patricia, Bernard Louis, Nau Pascale, Delobel Pierre, Balsarin Florence, De Lavaissiere Marc, Verdon Renaud, Feret Philippe, Jacomet Christine, Piroth Lionel, Gohier Sandrine, Leclercq Pascale, Gerberon ••••, Meybeck Agnés, Biekre Raphaël, May Thierry, Bouillon ••••, Caron François, Debab Yasmine, Theron David, Gatfosse Marc, Martinot Martin, Pachart Anne, Poubeau Patrice, Gaud Catherine, Uludag Agnès, Arsac Philippe, Bouaraba Lydia, Hocqueloux Laurent, de Dieulevault Barbara, De Lacroix Szmania Isabelle, Richier Laurent, Daneluzzi Vincent, Rouveix Elisabeth, Beck-Wirth Geneviève, Romand Philippe, Blum Laurent, Deschaud Martine, Michau Christophe, Bernard Christian, Salaun Florence, Muller Philippe, Poinsignon Yves, Lepretre Annie, Deschaud Martine, Sotto Albert, Doncesco ••••, Perfezou Pascale, Duthe Jean Charles, Niault Mathilde Aurore, Mouton-Rioux Virginie, Talarmin Jean-Philippe, Duthé Jean Charles, Dupont Mathilde, Natur Stéphane, Hitoto Hikombo, Ibrahim Ali Mahamadou
Affiliation:
1. Université Paris Cité, Faculté de Médecine, Paris, France 2. INSERM U1016, CNRS UMR8104, Institut Cochin, Paris, France 3. AP-HP, Laboratoire de Virologie, Hôpital Cochin, Paris, France 4. Institut Pasteur, Université de Paris, Unité Bio-informatique Evolutive, Paris, France 5. Institut Pasteur, Université de Paris, Hub Bioinformatique et Biostatistiques, Paris, France 6. INSERM CESP U1018, Université Paris Sud, Le Kremlin Bicêtre, France 7. Institut Pasteur, HIV Inflammation et Persistance, Paris, France 8. Institut de Systématique, Evolution, Biodiversité (ISYEB), UMR 7205–CNRS, Muséum National d’Histoire Naturelle, SU, EPHE UA, Paris, France 9. AP-HP, Hôpital Bicêtre, UMR1184, Université Paris Saclay, Inserm, CEA, Le Kremlin Bicêtre, France 10. Service des Maladies Infectieuses et Tropicales, CHR d’Orléans—La Source, Orléans, France 11. AP-HP, Laboratoire de Microbiologie Clinique, Hôpital Necker-Enfants Malades, Paris, France
Abstract
Most people living with HIV need antiretroviral therapy to control their infection and experience viral relapse in case of treatment interruption, because of viral reservoir (proviruses) persistence. Knowing that proviruses are very diverse and most of them are defective in treated individuals, we aimed to characterize the HIV blood reservoirs of posttreatment controllers (PTCs), rare models of drug-free remission, in comparison with spontaneous controllers and treated individuals.
Funder
Agence Nationale de Recherches sur le Sida et les Hépatites Virales HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
Cited by
6 articles.
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