Analytical Sensitivity of Eight Different SARS-CoV-2 Antigen-Detecting Rapid Tests for Omicron-BA.1 Variant-Reference-Cited by-同舟云学术

Analytical Sensitivity of Eight Different SARS-CoV-2 Antigen-Detecting Rapid Tests for Omicron-BA.1 Variant

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bekliz Meriem¹^ORCID,Adea Kenneth¹,Puhach Olha¹,Perez-Rodriguez Francisco²,Marques Melancia Stéfane²,Baggio Stephanie³,Corvaglia Anna-Rita¹,Jacquerioz Frederique⁴⁵⁶,Alvarez Catia¹,Essaidi-Laziosi Manel¹,Escadafal Camille⁷,Kaiser Laurent²⁴⁸,Eckerle Isabella¹⁴⁸^ORCID

Affiliation:

1. Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

2. Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland

3. Division of Prison Health, Geneva University Hospitals & University of Geneva, Geneva, Switzerland

4. Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland

5. Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland

6. Primary Care Division, Geneva University Hospitals, Geneva, Switzerland

7. FIND, Geneva, Switzerland

8. Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland

Abstract

Sensitivity for detecting Omicron-BA.1 shows high heterogenicity between Ag-RDTs, necessitating a careful consideration when using these tests to guide infection prevention measures. Analytical and retrospective testing is a proxy and timely solution to generate rapid performance data, but it is not a replacement for clinical evaluations, which are urgently needed. Biological and technical reasons for detection failure by some Ag-RDTs need to be further investigated.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

FIND

Hôpitaux Universitaires de Genève

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00853-22

Reference30 articles.

1. SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus

2. World Health Organization. 2020. Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays. World Health Organization Geneva Switzerland. https://www.who.int/publications/i/item/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays. Accessed 28 April 2021.

3. Rethinking Covid-19 Test Sensitivity — A Strategy for Containment

4. World Health Organization. 2021. Weekly epidemiological update on COVID-19. World Health Organization Geneva Switzerland. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---10-august-2021.

5. World Health Organization. 2022. Tracking SARS-CoV-2 variants. World Health Organization Geneva Switzerland. https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/. Accessed 8 December 2021.

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