Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site-Reference-Cited by-同舟云学术

Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Obata Shoko¹,Hisatsune Junzo²³⁴^ORCID,Kawasaki Hiroshi¹⁵⁶,Fukushima-Nomura Ayano¹,Ebihara Tamotsu¹,Arai Chika³⁴,Masuda Kanako³⁴,Kutsuno Shoko²³,Iwao Yasuhisa²,Sugai Motoyuki²³⁴^ORCID,Amagai Masayuki¹⁵,Tanese Keiji¹

Affiliation:

1. Department of Dermatology, Keio University School of Medicine, Tokyo, Japan

2. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

3. Department of Antimicrobial Resistance, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

4. Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan

5. Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

6. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Abstract

While Staphylococcus aureus is a member of the normal human skin flora, its strong association with the onset of atopic dermatitis (AD) has been suggested. However, previous studies failed to assign specific clones relevant to disease activities.

Funder

Japan Agency for Medical Research and Development

Health and Labor Sciences Research Grant

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05239-22

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1. Atopic dermatitis

2. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis