Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites

Author:

Yu Jiayu1ORCID,Liu Tianlong1,Guo Qingyun2,Wang Zixu1,Chen Yaoxing1ORCID,Dong Yulan1ORCID

Affiliation:

1. Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

2. Milu Conservation Research Unit, Beijing Milu Ecological Research Center, Beijing, People’s Republic of China

Abstract

A high-fructose diet aggravated restraint stress-induced changes in the composition of the intestinal microbiome, in which the abundance of A. muciniphila was significantly increased. The high-fructose diet exacerbated restraint stress-induced the changes in the composition of the microbial metabolites, with taurine abundance being downregulated and histamine abundance upregulated.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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