CsrA Positively and Directly Regulates the Expression of the pdu , pocR , and eut Genes Required for the Luminal Replication of Salmonella Typhimurium-Reference-Cited by-同舟云学术

CsrA Positively and Directly Regulates the Expression of the pdu , pocR , and eut Genes Required for the Luminal Replication of Salmonella Typhimurium

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nava-Galeana Jessica¹,Yakhnin Helen²,Babitzke Paul²^ORCID,Bustamante Víctor H.¹^ORCID

Affiliation:

1. Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

2. Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

The regulatory mechanisms that control the expression of virulence genes are essential for bacteria to infect hosts. Salmonella has developed diverse regulatory mechanisms to colonize the host gut. For instance, the SirA-CsrB/CsrC-CsrA regulatory cascade controls the expression of the SPI-1 genes, which are required for this bacterium to invade intestinal epithelium cells and for the induction of an intestinal inflammatory response.

Funder

UNAM | Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01516-23

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