Role of Toll-Like Receptor 4 in Mycobacterium avium subsp. <i>paratuberculosis</i> Infection of Bovine Mammary Epithelial (MAC-T) Cells <i>In Vitro</i>-Reference-Cited by-同舟云学术

Role of Toll-Like Receptor 4 in Mycobacterium avium subsp. paratuberculosis Infection of Bovine Mammary Epithelial (MAC-T) Cells In Vitro

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Shandilya Umesh K.¹,Wu Xiang¹,McAllister Caitlin¹,Mutharia Lucy²,Karrow Niel A.¹^ORCID

Affiliation:

1. Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada

2. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent for paratuberculosis or Johne’s disease (JD) in ruminants, a disease clinically very similar to Crohn’s disease in humans. Polymorphisms in the bovine Toll-like receptor genes ( TLR1 , TLR2 , and TLR4 ) have been shown to affect MAP recognition and host innate immune response and have been associated with increased susceptibility of cattle to paratuberculosis.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04393-22

Reference57 articles.

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