Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP-Reference-Cited by-同舟云学术

Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liang Ziwei¹,Rybtke Morten¹,Kragh Kasper Nørskov¹^ORCID,Johnson Owen¹,Schicketanz Muriel²,Zhang Yong Everett²,Andersen Jens Bo¹,Tolker-Nielsen Tim¹^ORCID

Affiliation:

1. Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Biology, Copenhagen Biocenter, University of Copenhagen, Copenhagen, Denmark

Abstract

The proliferation of alginate-overproducing P. aeruginosa variants in the lungs of cystic fibrosis patients often leads to chronic infection. The alginate functions as a biofilm matrix that protects the bacteria against host immune defenses and antibiotic treatment.

Funder

China Scholarship Council

Danmarks Frie Forskningsfond

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00675-22

Reference54 articles.

1. Pseudomonas aeruginosabiofilm infections: From molecular biofilm biology to new treatment possibilities

2. Pseudomonas aeruginosa infections in patients, hospital means, and personnel’s specimens;Fazeli H;J Res Med Sci,2012