Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-ResistantKlebsiella pneumoniae

Abstract

Here, we presentin vitroandin vivodata for thewzi50CPS-specific monoclonal antibody MAb 24D11, demonstrating its cross-protective efficacy against three prominentwintypes (wzi29,wzi154, andwzi50) of the carbapenem-resistant clonal group CG258. In a murine pulmonary infection model, MAb 24D11 reduced bacterial lung burden and dissemination to other organs even if administered 4 h postinfection.