Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies-Reference-Cited by-同舟云学术

Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Abd Alhadi Marwa¹²,Friedman Lilach M.¹²,Karlsson Erik A.³⁴^ORCID,Cohen-Lavi Liel²⁵,Burkovitz Anat¹²,Schultz-Cherry Stacey⁴^ORCID,Noah Terry L.⁶,Weir Samuel S.⁷,Shulman Lester M.⁸,Beck Melinda A.⁹,Hertz Tomer¹²¹⁰^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

2. National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel

3. Virology Unit, Institute Pasteur du Cambodge, Phnom Penh, Cambodia

4. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

5. Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel

6. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

8. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

9. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA

10. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

Obesity is associated with increased morbidity and mortality from influenza and SARS-CoV-2 infection. While vaccination is the most effective strategy for preventing influenza virus infection, our previous studies showed that influenza vaccines fail to provide optimal protection in obese individuals despite reaching canonical correlates of protection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Israel Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00010-23

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