Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation

Author:

Wu Fang1,Chen Xin1,Ma Yanhong1,Wu Yuzhe1,Li Rui1,Huang Yuanwei1,Zhang Rong2ORCID,Zhou Yaoqi3,Zhan Jian3,Liu Shuwen1ORCID,Xu Wei1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

3. Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China

Abstract

COVID-19, caused by the novel coronavirus SARS-CoV-2 virus, has triggered a global outbreak. The virus’s continuous mutation increases its infectivity and may be directly related to the immune escape response of viral proteins.

Funder

MOST | National Natural Science Foundation of China

Shenzhen Bay Laboratory

State Key Laboratory of Respiratory Disease

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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