The Mitochondrial Pyruvate Carrier Coupling Glycolysis and the Tricarboxylic Acid Cycle Is Required for the Asexual Reproduction of Toxoplasma gondii

Author:

Lyu Congcong123,Chen Yukun1,Meng Yanan1,Yang Jichao1,Ye Shu1,Niu Zhipeng1,EI-Debs Issam3,Gupta Nishith134ORCID,Shen Bang1526ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei Province, People’s Republic of China

2. Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Shenzhen, Guangdong Province, People’s Republic of China

3. Department of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany

4. Intracellular Parasite Education and Research Labs (iPEARL), Department of Biological Sciences, Birla Institute of Technology and Science, Pilani (BITS-P), Hyderabad, India

5. Hubei Hongshan Laboratory, Wuhan, Hubei Province, People’s Republic of China

6. Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong Province, People’s Republic of China

Abstract

T. gondii is a zoonotic parasite capable of infecting many warm-blooded organisms, including humans. Among others, a feature that allows it to parasitize multiple hosts is its exceptional metabolic plasticity.

Funder

HZAU-AGIS Cooperation Fund

German Research Foundation

Sino-German Science Center Mobility Programme

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Two enzymes contribute to citrate production in the mitochondrion of Toxoplasma gondii;Journal of Biological Chemistry;2024-08

2. A pyruvate transporter in the apicoplast of apicomplexan parasites;Proceedings of the National Academy of Sciences;2024-06-12

3. Mechanisms of adaptation and evolution in Toxoplasma gondii;Molecular and Biochemical Parasitology;2024-06

4. Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis;Frontiers in Cellular and Infection Microbiology;2023-05-23

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