The Association between Circulating microRNAs and the Risk of Active Disease Development from Latent Tuberculosis Infection: a Nested Case-Control Study

Author:

Xin Henan1,Cao Xuefang1,Du Ying1,Yan Jiaoxia2,He Rui3,Liu Zisen2,Zhang Haoran1,He Yijun1,Zhang Bin2,Wang Dakuan2,Guan Ling3,Shen Fei3,Feng Boxuan1,Quan Zhusheng1,He Yongpeng1,Liu Jianmin3,Jin Qi1,Pan Shouguo2,Gao Lei1ORCID

Affiliation:

1. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

2. Center for Diseases Control and Prevention of Zhongmu, Zhengzhou, People’s Republic of China

3. Sixth People’s Hospital of Zhengzhou, Zhengzhou, People’s Republic of China

Abstract

Approximately a quarter of the world population are infected with M. tuberculosis and about 5% to 10% of these might develop active disease in their lifetime. Preventive treatment could effectively protect individuals at a high risk of developing active disease from LTBI, and is regarded as a critical component of End TB Strategies.

Funder

CAMS Innovation Fund For Medical Sciences

National Natural Science Foundation of China

National Science and Technology Major Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference28 articles.

1. WHO. 2020. Global tuberculosis report 2020. WHO Geneva Switzerland. Available from: https://apps.who.int/iris/handle/10665/336069?locale-attribute=en&. Accessed 24 December 2020.

2. WHO. 2020. WHO consolidated guidelines on tuberculosis. Module 1: Prevention. Tuberculosis preventive treatment. WHO Geneva Switzerland. Available from: https://www.who.int/publications-detail/who-consolidated-guidelines-on-tuberculosis-module-1-prevention-tuberculosis-preventive-treatment. Accessed 24 March 2020.

3. MicroRNAs as regulatory elements in immune system logic

4. Fine‐tuning of the innate immune response by microRNAs

5. Micromanagement of the immune system by microRNAs

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