The Influence of Adjuvant Type on the Immunogenicity of RBD/N Cocktail Antigens as a Vaccine Candidate against SARS-CoV-2 Virus-Reference-Cited by-同舟云学术

The Influence of Adjuvant Type on the Immunogenicity of RBD/N Cocktail Antigens as a Vaccine Candidate against SARS-CoV-2 Virus

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Brzuska Gabriela¹^ORCID,Zimna Marta¹^ORCID,Baranska Klaudia¹^ORCID,Szewczyk Boguslaw¹,Strakova Petra²³,Ruzek Daniel²³⁴^ORCID,Krol Ewelina¹^ORCID

Affiliation:

1. Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland

2. Laboratory of Emerging Viral Infections, Veterinary Research Institute, Brno, Czech Republic

3. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic

4. Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

Abstract

Although several COVID-19 vaccines have been approved worldwide, continuous emergence of new SARS-CoV-2 variants calls for new efficient vaccines against them, providing long-lasting immunity. As the immune response after vaccination is dependent not only on antigen used, but also on other vaccine components, e.g., adjuvants, the purpose of this work was to study the effect of different adjuvants on the immunogenicity of RBD/N SARS-CoV-2 cocktail proteins.

Funder

Narodowe Centrum Nauki

Czech Ministry of Agriculture

European Union - Next Generation EU

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02564-22

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