Novel Preclinical Study of Galloylquinic Acid Compounds from <i>Copaifera lucens</i> with Potent Antifungal Activity against Vaginal Candidiasis Induced in a Murine Model via Multitarget Modes of Action-Reference-Cited by-同舟云学术

Novel Preclinical Study of Galloylquinic Acid Compounds from Copaifera lucens with Potent Antifungal Activity against Vaginal Candidiasis Induced in a Murine Model via Multitarget Modes of Action

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Al-Madboly Lamiaa A.¹^ORCID,Abd El-Salam Mohamed A.²³⁴^ORCID,Bastos Jairo K.⁵,El-Shorbagy Safinaz H.⁶,El-Morsi Rasha M.⁷

Affiliation:

1. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Tanta University, Tanta, Egypt

2. Institute for Research in Biomedicine Barcelona, The Barcelona Institute of Science and Technology, Barcelona, Spain

3. Department of Pharmacognosy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt

4. Department of Medicine, Harvard Medical School, Harvard University, Program in Research at VA West Roxbury, Massachusetts, USA

5. Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

6. Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

7. Department of Microbiology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt

Abstract

Our work presents a new perspective on the potential use of GQAs as safe and highly effective phytochemicals against MDR C. albicans . This microorganism colonizes the human vaginal epithelium, causing vaginal candidiasis, a condition characterized by recurrent pathogenicity and tolerance to traditional antifungal therapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02724-21

Reference58 articles.

1. Invasive candidiasis

2. Biomarkers for the diagnosis of invasive candidiasis in immunocompetent and immunocompromised patients

3. Plants' natural products as alternative promising anti-Candida drugs

4. Isolation and Characterization of Bacterial Cellulase Producers for Biomass Deconstruction: A Microbiology Laboratory Course

5. Vulvovaginal Candidosis: Current Concepts, Challenges and Perspectives

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. New arsenals for old armour: Biogenic nanoparticles in the battle against drug-resistant Candida albicans;Microbial Pathogenesis;2024-09

2. Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes;Microbial Cell Factories;2024-08-08

3. From plants to particles: herbal solutions and nanotechnology combating resistant vulvovaginal candidiasis;Therapeutic Delivery;2024-04-23

4. Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation;Phytotherapy Research;2024-03-07

5. The growth inhibitory and apoptotic effects of umbelliprenin in a mouse model of systemic candidiasis;Journal of Applied Microbiology;2023-09