Dissemination of Tn <i>916</i> -Related Integrative and Conjugative Elements in Streptococcus pneumoniae Occurs by Transformation and Homologous Recombination in Nasopharyngeal Biofilms-Reference-Cited by-同舟云学术

Dissemination of Tn 916 -Related Integrative and Conjugative Elements in Streptococcus pneumoniae Occurs by Transformation and Homologous Recombination in Nasopharyngeal Biofilms

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Antezana Brenda S.¹^ORCID,Lohsen Sarah²,Wu Xueqing³,Vidal Jorge E.⁴^ORCID,Tzeng Yih-Ling²^ORCID,Stephens David S.²^ORCID

Affiliation:

1. Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Emory University Laney Graduate School, Atlanta, Georgia, USA

2. Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA

3. Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou, China

4. Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA

Abstract

The World Health Organization has designated Streptococcus pneumoniae as a priority pathogen for research and development of new drug treatments due to extensive multidrug resistance. Multiple strains of S. pneumoniae colonize and form mixed biofilms in the human nasopharynx, which could enable exchange of antibiotic resistance determinants.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03759-22

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