Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium-Reference-Cited by-同舟云学术

Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Thapa Jeewan¹^ORCID,Chizimu Joseph Yamweka¹²,Kitamura Soyoka³,Akapelwa Mwangala Lonah¹,Suwanthada Pondpan¹,Miura Nami¹,Toyting Jirachaya¹,Nishimura Tomoyasu⁴,Hasegawa Naoki⁵^ORCID,Nishiuchi Yukiko⁶⁷^ORCID,Gordon Stephen V.⁸⁹^ORCID,Nakajima Chie¹⁹¹⁰,Suzuki Yasuhiko¹⁹¹⁰

Affiliation:

1. Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

2. Zambian National Public Health Institute, Ministry of Health, Lusaka, Zambia

3. Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

4. Keio University Health Center, Tokyo, Japan

5. Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan

6. Toneyama Institute for Tuberculosis Research, Osaka City University Medical School, Osaka, Japan

7. Office of Academic Research and Industry-Government Collaboration, Section of Microbial Genomics and Ecology, Hiroshima University, Higashi-Hiroshima, Japan

8. School of Veterinary Medicine, University College Dublin, Dublin, Ireland

9. International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

10. Institute for Vaccine Research and Development, Hokkaido University, Sapporo, Japan

Abstract

The emergence of fluoroquinolone (FQ) resistance has further compounded the control of emerging Mycobacterium avium -associated nontuberculous mycobacteria infections worldwide. For M. avium , the association of FQ resistance and mutations in the quinolone resistance-determining region (QRDR) of gyrA is not yet clearly understood.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05088-22

Reference49 articles.

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2. The new phylogeny of the genus Mycobacterium : The old and the news

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5. Epidemiology of Pulmonary Nontuberculous Mycobacterial Disease, Japan1

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