Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of <i>Mycobacterium tuberculosis</i> Infections in Immunocompromised Patients: a Real-World Study-Reference-Cited by-同舟云学术

Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of Mycobacterium tuberculosis Infections in Immunocompromised Patients: a Real-World Study

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Xu Yuzhen¹,Yang Qingluan¹,Zhou Jingyu¹,Zhou Feiran¹,Hezhang Yufan¹,Gao Yan¹,Shao Lingyun¹,Shi Jichan²,Ruan Qiaoling¹^ORCID,Zhang Wenhong¹³⁴

Affiliation:

1. Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China

2. Departments of Infectious Disease, Wenzhou Central Hospital, the Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

3. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

4. Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

Abstract

This study evaluated the performance of QFT-GIT and QFT-Plus in the diagnosis of M. tuberculosis infection in immunocompromised patients and found that QFT-Plus may detect more LTBI than QFT-GIT does in patients receiving long-term immunosuppressant therapy. We believe that our study makes a significant contribution to the literature because it highlights the different diagnostic accuracies of QFT-GIT and QFT-Plus in different subpopulations of immunocompromised and immunocompetent patients.

Funder

Shanghai Science and Technology Development Foundation

上海市教育委员会 | Shanghai Key Discipline Construction Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01870-21

Reference34 articles.

1. World Health Organization. 2020. Global tuberculosis report 2020. WHO, Geneva, Switzerland.

2. The challenge of new drug discovery for tuberculosis