RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature-Reference-Cited by-同舟云学术

RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Shuyi¹,Wu Jiqin²^ORCID,Yang Xiaofeng³^ORCID,Sun Qiuli³,Liu Su³,Rashid Farooq¹,Dzakah Emmanuel Enoch⁴,Wang Haiying¹,Wang Jufang³^ORCID,Gong Peng²⁵^ORCID,Tang Shixing¹^ORCID

Affiliation:

1. Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China

2. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

3. School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China

4. Department of Molecular Biology & Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana

5. Drug Discovery Center for Infectious Diseases, Nankai University, Tianjin, China

Abstract

RNA viruses represent the most important pathogens for humans and animals and exhibit rapid evolution and high adaptive capacity, which is due to the high mutation rates for using the error-prone RNA-dependent RNA polymerase (RdRp) during replication. The fidelity of RdRp is closely associated with viral diversity, fitness, and pathogenesis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Bureau of Science and Information Technology of Guangzhou Municipality | Key Technologies Research and Development Program of Guangzhou

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02729-22

Reference38 articles.

1. Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses