Impact of Empirical Antibiotic Therapy on Outcomes of Outpatient Urinary Tract Infection Due to Nonsusceptible Enterobacterales

Author:

Dunne Michael W.1,Puttagunta Sailaja1,Aronin Steven I.1ORCID,Brossette Stephen2,Murray John2,Gupta Vikas2

Affiliation:

1. Iterum Therapeutics, Old Saybrook, Connecticut, USA

2. Becton, Dickinson and Company, Franklin Lakes, New Jersey, USA

Abstract

Resistance rates for bacteria that cause urinary tract infections (UTIs) have increased dramatically. Regional rates of resistance to commonly prescribed antibiotics now exceed 20%, which is the threshold at which the Infectious Diseases Society of America recommends therapy be guided by culture.

Funder

Iterum Therapeutics

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference18 articles.

1. The Increase in Hospitalizations for Urinary Tract Infections and the Associated Costs in the United States, 1998–2011

2. Symphony Healthcare. 2018. Ad hoc report performed for Iterum Therapeutics. Symphony Healthcare Phoenix AZ. Available at https://data.bloomberglp.com/professional/sites/10/Symphony-Health-In-Action.pdf.

3. Ambulatory medical care utilization estimates for 2007. National Center for Health Statistics;Schappert SM;Vital Health Stat 13,2011

4. Urinary tract infections: epidemiology, mechanisms of infection and treatment options

5. CDC. 2019. CDC summary data. https://cdc.gov/gis/interactive-applications.htm. Accessed 20 May 2019.

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