Antimicrobial Activity of Ceftolozane-Tazobactam, Ceftazidime-Avibactam, and Cefiderocol against Multidrug-Resistant Pseudomonas aeruginosa Recovered at a German University Hospital-Reference-Cited by-同舟云学术

Antimicrobial Activity of Ceftolozane-Tazobactam, Ceftazidime-Avibactam, and Cefiderocol against Multidrug-Resistant Pseudomonas aeruginosa Recovered at a German University Hospital

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Weber C.¹,Schultze T.¹²,Göttig S.¹,Kessel J.³,Schröder A.¹⁴,Tietgen M.¹²,Besier S.¹⁴,Burbach T.¹,Häussler S.⁵⁶,Wichelhaus T. A.¹,Hack D.¹²,Kempf V. A. J.¹²^ORCID,Hogardt M.¹⁴^ORCID

Affiliation:

1. Institute for Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany

2. University Center of Competence for Infection Control of the State of Hesse, Frankfurt am Main, Germany

3. Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany

4. German National Consiliary Laboratory on Cystic Fibrosis Bacteriology, Frankfurt am Main, Germany

5. Department of Molecular Bacteriology, Helmholtz Center for Infection Research, Braunschweig, Germany

6. Department of Clinical Microbiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

Abstract

After testing ceftolozane-tazobactam, ceftazidime-avibactam, and cefiderocol against a collection of 233 multidrug-resistant (MDR) Pseudomonas aeruginosa , we showed that cefiderocol is the most active antipseudomonal β-lactam agent (susceptibility rates were 46.6%, 48.4%, and 97.4%, respectively). The most prevalent one was sequence type 235 (ST235) (24.7%), followed by ST244, ST175, and ST233, with all belonging to the top 10 P. aeruginosa high-risk clones with worldwide distribution.

Funder

Bundesministerium für Gesundheit

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01697-22

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