Oral Immunization with AttenuatedSalmonellaCholeraesuis Expressing the P42 and P97 Antigens Protects Mice againstMycoplasma hyopneumoniaeChallenge

Author:

Zhou Guodong12,Tian Yichen12,Tian Jiashuo12,Ma Qifeng12,Huang Shan12,Li Quan12,Wang Shifeng3,Shi Huoying124ORCID

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China

2. Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China

3. Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA

4. Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University (JIRLAAPS), Yangzhou, China

Abstract

Mhp is the main pathogen of porcine enzootic pneumonia, a highly infectious and economically significant respiratory disease that affects pigs of all ages. As the target tissue of Mhp infections are the mucosal sites of the respiratory tract, the induction of protective immunity at the mucosal tissues is the most efficient strategy by which to block disease transmission.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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