Latent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis-Burden Area: a Comparison between Transcript Signature and Interferon Gamma Release Assay-Reference-Cited by-同舟云学术

Latent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis-Burden Area: a Comparison between Transcript Signature and Interferon Gamma Release Assay

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kaul Sheetal¹²,Nair Vivek¹,Birla Shweta¹,Dhawan Shikha³⁴,Rathore Sumit⁵,Khanna Vishal⁶,Lohiya Sheelu⁶,Ali Shakir²,Mannan Shamim⁷,Rade Kirankumar⁷,Malhotra Pawan¹^ORCID,Gupta Dinesh¹^ORCID,Khanna Ashwani⁶,Mohmmed Asif¹^ORCID

Affiliation:

1. International Centre for Genetic Engineering and Biotechnology, New Delhi, India

2. Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India

3. Partasia Biopharm, New Delhi, India

4. Society for Health Allied Research & Education (SHARE INDIA), New Delhi, India

5. All India Institute of Medical Sciences, New Delhi, India

6. Chest Clinic (Tuberculosis), Lok Nayak Hospital, New Delhi, India

7. WHO-India Country Office, New Delhi, India

Abstract

The study compares potential of transcript signature and IGRA to diagnose LTBI. It is first of its kind study to screen household contacts (HHCs) in high TB burden area of India. A transcript signature ( FCGR1B, GBP1 , & GBP5 ) is identified as potential biomarker for LTBI. These results can lead to development of point-of-care (POC) like device for LTBI screening in a high TB burdened area.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Grand Challenges Exploration, BIRAC

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02445-21

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