Studies on the Transmission of a Tigecycline Resistance-Mediating <i>tet</i> (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process-Reference-Cited by-同舟云学术

Studies on the Transmission of a Tigecycline Resistance-Mediating tet (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yu Runhao¹,Chen Zheng¹,Li Danyang¹,Schwarz Stefan²³^ORCID,Wang Xinwei¹,Du Xiang-Dang¹^ORCID

Affiliation:

1. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, People’s Republic of China

2. Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

3. Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, Berlin, Germany

Abstract

Tigecycline is an important last-resort broad spectrum antimicrobial agent. This study describes the two-step recombination processes resulting in the transfer of the tet (A) variant gene between different plasmids in E. hormaechei , which depicts the role of recombination processes in the generation of UCSs and new plasmids, both carrying a tet (A) variant conferring resistance to tigecycline.

Funder

National Natural Science Foundation of China

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00496-22

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