Concentrative Nucleoside Transporter, CNT, Results in Selective Toxicity of Toyocamycin against Candida albicans

Author:

Ojima Yoshihiro1ORCID,Yokota Naoki1,Tanibata Yuki1,Nerome Shinsuke1,Azuma Masayuki1ORCID

Affiliation:

1. Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan

Abstract

We investigated the mechanism of toxicity of TM and its analogs to C. albicans . Inspired by the effect of the copresence of TM and purine nucleosides on cell growth of C. albicans , we investigated the involvement of CNT in the toxicity mechanism by expressing CNT of C. albicans (CaCNT) in S. cerevisiae and deleting CaCNT in C. albicans .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference27 articles.

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2. Chemical structure of toyocamycin;Ohkuma K;J Antibiot Ser A,1960

3. A new antibiotic, tubercidin;Anzai K;J Antibiot Ser A,1957

4. Chemical structure of toyocamycin;Suzuki S;J Antibiot Ser A,1960

5. Synthetic Studies of Potential Antimetabolites. IX. The Anomeric Configuration of Tubercidin

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