Clinical Evaluation of a Line-Probe Assay for Tuberculosis Detection and Drug-Resistance Prediction in Namibia-Reference-Cited by-同舟云学术

Clinical Evaluation of a Line-Probe Assay for Tuberculosis Detection and Drug-Resistance Prediction in Namibia

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Günther G.¹²³^ORCID,Saathoff E.⁴⁵,Rachow A.⁴⁵,Ekandjo H.²,Diergaardt A.²,Marais N.²,Lange C.⁶⁷⁸⁹,Nepolo E.²

Affiliation:

1. Department of Pulmonology and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Department of Human, Biological and Translational Medical Sciences, School of Medicine, University of Namibia, Windhoek, Namibia

3. Department of Medicine, Katutura State Hospital, Windhoek, Namibia

4. Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany

5. German Centre for Infection Research (DZIF), Partner Site Munich, Germany

6. Research Center Borstel, Leibniz Lung Center, Borstel, Germany

7. Tuberculosis Unit, German Center for Infection Research (DZIF), Borstel, Germany

8. Respiratory Medicine & International Health, University Lübeck, Lübeck, Germany

9. Baylor College of Medicine and Texas Children's Hospital, Global TB Program, Houston, Texas, USA

Abstract

Mycobacterium tuberculosis ( Mtb ) drug-resistance detection is crucial for successful control of tuberculosis. Line-probe assays (LPA) are frequently used to detect resistance to rifampin, isoniazid, fluoroquinolones (FQs), and second-line injectables (SLIs).

Funder

Autoimmundiagnostics GmbH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00259-22

Reference22 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021. License: CC BY-NC-SA 3.0 IGO. World Health Organization Geneva Switzerland.

2. World Health Organization. 2021. WHO consolidated guidelines on tuberculosis. Module 3: diagnosis–rapid diagnostics for tuberculosisdetection 2021 update. License: CC BY-NC-SA 3.0 IGO. World Health Organization Geneva Switzerland.

3. Global Laboratory Initiative. 2018. Line probe assays for drug-resistant tuberculosis detection interpretation and reporting guide for laboratory staff and clinicians. https://stoptb.org/wg/gli/assets/documents/LPA_test_web_ready.pdf. Accessed 20 February 2022.

4. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis

5. Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment

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