Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes-Reference-Cited by-同舟云学术

Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Dong Xiaofeng¹,Tree Julia²,Banadyga Logan³,He Shihua³,Zhu Wenjun³,Tipton Tom²,Gouriet Jade²,Qiu Xiangguo³,Elmore Michael J.²,Hall Yper²,Carroll Miles⁴⁵,Hiscox Julian A.¹⁶^ORCID

Affiliation:

1. Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom

2. UK-Health Security Agency, Salisbury, United Kingdom

3. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

4. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom

5. Pandemic Sciences Institute, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom

6. Infectious Diseases Horizontal Technology Centre (ID HTC), A*STAR, Singapore, Singapore

Abstract

Ebola virus infection can have dramatic effects on the human body which manifest in Ebola virus disease. The outcome of infection is either survival or death and in the former group with the potential of longer-term health consequences and persistent infection.

Funder

UK Health Security Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04154-22

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5. Human Ebola virus infection results in substantial immune activation

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