Vaccine-Induced Antibody Responses against SARS-CoV-2 Variants-Of-Concern Six Months after the BNT162b2 COVID-19 mRNA Vaccination-Reference-Cited by-同舟云学术

Vaccine-Induced Antibody Responses against SARS-CoV-2 Variants-Of-Concern Six Months after the BNT162b2 COVID-19 mRNA Vaccination

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Jalkanen Pinja¹^ORCID,Kolehmainen Pekka¹^ORCID,Haveri Anu²,Huttunen Moona¹,Laine Larissa²,Österlund Pamela²^ORCID,Tähtinen Paula A.³,Ivaska Lauri³,Maljanen Sari¹,Reinholm Arttu¹,Belik Milja¹,Smura Teemu⁴,Häkkinen Hanni K.⁵,Ortamo Eeva⁵,Kantele Anu⁵,Julkunen Ilkka¹⁶,Lempainen Johanna³⁶⁷,Kakkola Laura¹

Affiliation:

1. Institute of Biomedicine, University of Turku, Turku, Finland

2. Finnish Institute for Health and Welfare, Helsinki, Finland

3. Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland

4. Department of Virology, University of Helsinki, Helsinki, Finland

5. Meilahti Infectious Diseases and Vaccine Research Center, MeiVac, Department of Infectious Diseases, University Hospital and University of Helsinki, Helsinki, Finland

6. Clinical Microbiology, Turku University Hospital, Turku, Finland

7. Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland

Abstract

A decrease in vaccine efficacy against emerging SARS-CoV-2 variants has increased the importance of assessing the persistence of SARS-CoV-2 spike protein-specific antibodies and neutralizing antibodies. Our data show that after 6 months post two doses of BNT162b2 vaccine, antibody levels decrease yet remain detectable and capable of neutralizing emerging variants. By monitoring the vaccine-induced antibody responses, vaccination strategies and administration of booster doses can be optimized.

Funder

Academy of Finland

Jane ja Aatos Erkon Säätiö

Sigrid Juséliuksen Säätiö

Suomen Lääketieteen Säätiö

Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimussäätiö

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02252-21

Reference30 articles.

1. Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021

2. WHO. 2021. Tracking SARS-CoV-2 variants. World Health Organization Geneva Switzerland.

3. CDC. 2021. SARS-CoV-2 variant classifications and definitions. CDC, Atlanta, GA.

4. SARS-CoV-2 variants of concern are emerging in India

5. WHO. 2021. Weekly epidemiological update on COVID-19—20 July 2021. World Health Organization, Geneva, Switzerland.

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhancing Immunological Memory: Unveiling Booster Doses to Bolster Vaccine Efficacy Against Evolving SARS-CoV-2 Mutant Variants;Current Microbiology;2024-02

2. Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses;Biomolecules;2023-09-26

3. Long follow-up of BNT162b2 mRNA vaccine in healthcare workers (2020–2022): A retrospective longitudinal SARS-CoV-2 serological surveillance;Human Vaccines & Immunotherapeutics;2023-08

4. Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose;Frontiers in Immunology;2023-01-23

5. IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study;Frontiers in Cellular and Infection Microbiology;2022-11-30